Well, my experience is that using cruise will generally be more economical for maintaining a steady speed than trying to do it manually. Admittedly, I don't have experience with cruise on the Omega (I haven't had it enabled yet) but my previous 4 cars (a Volvo V40, Jeep Grand Cherokee Auto and 2 Jaguar 2.5 V6 X-Type Autos) all had cruise and cruise would definitely improve mpg by 3-4 over a longish distance compared with not using it.
I think the important element here is the "given speed". When controlling manually speed will rise and fall due to the road surface, hills, bends and even just lack of concentration. I find that my speed will often creep up beyond my target, or fall behind it, maybe just because I fall in line with other traffic or the road becomes clear - especially over long distances (>100 miles). Adjusting speed manually will always use more fuel than letting the computer take control because my foot is less subtle than the cruise.
But, as they often say, Your Mileage May Vary.
Jim.